The 2025 CONCACAF Gold Cup is well underway, and the possibility of a USA vs. Mexico final is generating significant buzz, especially concerning betting odds and potential handle. The tournament, co-hosted by the United States and Canada, began on June 14th and will culminate on July 6th at NRG Stadium in Houston, Texas.

As of today, June 25, 2025, the tournament has reached the knockout stage, with the quarterfinal matchups set. The United States will face Costa Rica, while Mexico will play against Saudi Arabia. Other quarterfinal matches include Panama vs. Honduras and Canada vs. Guatemala. These matchups have solidified the path toward the final, making the potential for a USA-Mexico clash all the more real.

The anticipation surrounding a potential USA-Mexico final is not unfounded. Both teams are perennial powerhouses in the CONCACAF region, with a rich history of rivalry and success in the Gold Cup. Mexico has won the tournament a record nine times, while the U.S. has seven titles. Their dominance is such that only once has a team other than these two lifted the trophy – Canada in 2000.

Currently, betting odds reflect the high expectations for both teams. Before the tournament began, Mexico was often listed as a slight favorite, with the USA close behind. For example, on June 12th, DraftKings Sportsbook had Mexico at +170 to win the tournament, with the USMNT at +200. FanDuel Sportsbook listed both USA and Mexico with +190 odds on the same date. These close odds underscore the perceived parity and the high likelihood of both teams making a deep run.

Several factors contribute to the high stakes and significant betting interest in a potential USA-Mexico final. The rivalry between the two nations is intense, drawing passionate fans and significant media attention. A final match between them would not only determine the champion of the CONCACAF region but also carry significant bragging rights. This is further amplified by the fact that the 2025 Gold Cup serves as a crucial "dress rehearsal" for the co-hosts, USA, Canada, and Mexico, of the 2026 FIFA World Cup.

The absence of several key players from the USMNT, due to various reasons, has added an element of unpredictability. However, strong performances from players like Malik Tillman and Patrick Agyemang have bolstered the team's chances. Meanwhile, Mexico, the defending champion, is aiming for their tenth Gold Cup title.

The quarterfinals, semifinals, and final are expected to draw substantial viewership and betting activity. The final on July 6th, marking the first time the Gold Cup Final will be hosted in Texas, will likely be a record-breaking event in terms of attendance and handle.

Ultimately, whether the USA and Mexico meet in the final remains to be seen, but the possibility is undeniably driving excitement and betting interest in the 2025 Gold Cup.