Liverpool is set to clash with Atletico Madrid at Anfield in a highly anticipated Champions League match, marking the start of their 2025-26 campaign. The focus is on whether Liverpool's record signing, Alexander Isak, will make his debut.

Isak's Potential Debut

Alexander Isak, who was signed for £125 million from Newcastle, could make his first appearance for Liverpool in this Champions League match. Despite the high expectations, manager Arne Slot has indicated that Isak is unlikely to start and won't play the full 90 minutes, as he eases into the team after missing pre-season training. According to journalist David Ornstein, Isak is expected to come off the bench. Virgil van Dijk has praised Isak as a "complete striker" with clinical finishing skills.

Team News and Injuries

Liverpool enters the match in strong form, having won all four of their Premier League games. However, midfielder Alexis Mac Allister is a game-time decision after suffering a knock in the previous match against Burnley. Curtis Jones is out with an unspecified injury. Jeremie Frimpong is back in contention after recovering from injury. Dominik Szoboszlai may move into Jones's defensive midfield role if Mac Allister is unavailable.

Atletico Madrid has several injury concerns following their 2-0 win against Villareal. Julian Alvarez is confirmed to be out, while Nico Gonzalez, Robin Le Normand, and David Hancko are doubtful. Despite these injuries, Atletico is coming off a win against Villarreal, with goals from Barrios and Nico.

Liverpool's European Record

Liverpool has a formidable home record in European competitions, winning their last 14 home games in the Champions League group stage. They have scored two or more goals in 13 of those matches. Mohamed Salah has an impressive record of 18 goals in his last 20 Champions League group stage matches for Liverpool.

Atletico's Form and History

Atletico Madrid has had a mixed start to their La Liga season and currently sits in 11th place. They have won 14, drawn 14, and lost 11 of their 39 previous matches against English teams. Diego Simeone has been in charge of Atletico since December 2011 and has a balanced record of two wins and two losses against Liverpool.

Match Details

The match will take place at Anfield, Liverpool, on Wednesday, September 17, 2025, with kickoff at 9 pm CEST. This game marks the beginning of Liverpool's 50th season of European football. The two clubs have met eight times previously, with three wins each.

Predicted Lineups

While the official lineups are yet to be announced, probable lineups have been suggested:

• Liverpool: Alisson, Frimpong, Konate, Van Dijk, Kerkez, Gravenberch, Mac Allister, Wirtz, Salah, Ekitike, Gakpo.
• Atletico Madrid: Oblak, Lenglet, Le Normand, Galan, Koke, Llorente, Gallagher, Barrios, Griezmann, Gonzalez, Simeone.