West Ham United and Brentford faced off in a Premier League match at the London Stadium on October 20, 2025, with both teams eager to improve their standing in the league. West Ham, positioned 19th, sought their first home points of the season, while 16th-place Brentford aimed to secure their first away points.

Nuno Espírito Santo, recently appointed as West Ham's manager, took charge at the London Stadium for the first time, replacing Graham Potter. He was seeking his first win since taking over, following a draw against Everton and a defeat against Arsenal. A key objective for Santo was to reverse West Ham's poor home form, as they had yet to secure a point at home this season. Furthermore, West Ham had lost all four of their Premier League London derbies this term, conceding two or more goals in six of their eight games overall.

Keith Andrews, Brentford's head coach, aimed to secure his first away victory as a Premier League manager. A win would elevate Brentford five points clear of the relegation zone, potentially moving them up to 13th place. However, Brentford's recent form had been inconsistent, with only one win in their last five league games. Despite this, they have had success against West Ham, winning six of their eight previous Premier League meetings, the most against any side.

The confirmed team news revealed that West Ham made five changes from their previous game against Arsenal. Tomáš Souček returned from suspension to feature in midfield alongside Andy Irving. Kyle Walker-Peters replaced Aaron Wan-Bissaka at right-back, Jean-Clair Todibo stepped in for Konstantinos Mavropanos at centre-back, and Ollie Scarles filled the left-back position. Brentford made one change, with Dango Ouattara replacing Aaron Hickey, joining Kevin Schade and Igor Thiago in attack.

West Ham lined up in a 4-2-3-1 formation: Alphonse Areola in goal; Kyle Walker-Peters, Jean-Clair Todibo, Max Kilman, and Ollie Scarles in defense; Andy Irving and Tomáš Souček in midfield; Jarrod Bowen, Mateus Fernandes, and Crysencio Summerville supporting Lucas Paquetá. Brentford countered with a 4-3-3 formation: Kelleher in goal; Kayode, Collins, Van den Berg, and Ajer in defense; Henderson, Yarmolyuk, and Damsgaard in midfield; and Ouattara, Schade, and Thiago leading the attack.

Nuno Espírito Santo expressed his intent to address West Ham's home form, while Keith Andrews aimed to capitalize on Brentford's favorable record against the Hammers.